2LU1

pfsub2 solution NMR structure

2LU1 の概要

• エントリーDOI: 10.2210/pdb2lu1/pdb
• NMR情報: BMRB: 18504
• 分子名称: Subtilase (1 entity in total)
• 機能のキーワード: sub2 inhibitor prodomain, hydrolase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17721.33

構造登録者

He, Y.,Chen, Y.,Ruan, B.,O'Brochta, D.,Bryan, P.,Orban, J. (登録日: 2012-06-06, 公開日: 2012-10-03, 最終更新日: 2024-05-01)

主引用文献

He, Y.,Chen, Y.,Oganesyan, N.,Ruan, B.,O'Brochta, D.,Bryan, P.N.,Orban, J.
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
Proteins, 80:2810-2817, 2012

PubMed Abstract: Plasmodium subtilisin 2 (Sub2) is a multidomain protein that plays an important role in malaria infection. Here, we describe the solution NMR structure of a conserved region of the inhibitory prodomain of Sub2 from Plasmodium falciparum, termed prosub2. Despite the absence of any detectable sequence homology, the protozoan prosub2 has structural similarity to bacterial and mammalian subtilisin-like prodomains. Comparison with the three-dimensional structures of these other prodomains suggests a likely binding interface with the catalytic domain of Sub2 and provides insights into the locations of primary and secondary processing sites in Plasmodium prodomains.

PubMed: 23011838
DOI: 10.1002/prot.24187

実験手法

SOLUTION NMR