2LTK

Solution structure of a monomeric truncated mutant of Trypanosoma brucei 1-C-Grx1

Summary for 2LTK

• Entry DOI: 10.2210/pdb2ltk/pdb
• NMR Information: BMRB: 18485
• Descriptor: Mono-cysteine glutaredoxin (1 entity in total)
• Functional Keywords: monothiol glutaredoxin, oxidoreductase
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 1
• Total formula weight: 12325.45

Authors

Pavan, C.,Gesiot, L.,Sturlese, M.,Mammi, S.,Manta, B.,Comini, M.,Bellanda, M. (deposition date: 2012-05-29, release date: 2013-05-08, Last modification date: 2024-05-01)

Primary citation

Manta, B.,Pavan, C.,Sturlese, M.,Medeiros, A.,Crispo, M.,Berndt, C.,Krauth-Siegel, R.L.,Bellanda, M.,Comini, M.A.
Iron-Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei: Molecular Basis of Iron-Sulfur Cluster Coordination and Relevance for Parasite Infectivity.
Antioxid Redox Signal, 19:665-682, 2013

PubMed Abstract: Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro using glutathione (GSH) as cofactor. We here report on the functional and structural analysis of 1-C-Grx1 in relation to its ISC-binding properties.

PubMed: 23259530
DOI: 10.1089/ars.2012.4859

Experimental method

SOLUTION NMR