2LR1

Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA

Summary for 2LR1

• Entry DOI: 10.2210/pdb2lr1/pdb
• Related: 1F16
• NMR Information: BMRB: 18340
• Descriptor: Apoptosis regulator BAX, Immediate early glycoprotein (2 entities in total)
• Functional Keywords: apoptosis-signaling protein complex, apoptosis/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm : Q07812; Isoform gpUL37: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Isoform vMIA: Host mitochondrion membrane ; Single-pass membrane protein . Isoform pUL37m: Host mitochondrion membrane ; Single-pass membrane protein : P16778
• Total number of polymer chains: 2
• Total formula weight: 23936.64

Authors

Ma, J. (deposition date: 2012-03-20, release date: 2012-12-05, Last modification date: 2017-02-22)

• Primary citation: Ma, J.,Edlich, F.,Bermejo, G.A.,Norris, K.L.,Youle, R.J.,Tjandra, N.; Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.; Proc.Natl.Acad.Sci.USA, 109:20901-20906, 2012; PubMed: 23213219; DOI: 10.1073/pnas.1217094110

Experimental method

SOLUTION NMR