2LQY

Structure and orientation of the gH625-644 membrane interacting region of herpes simplex virus type 1 in a membrane mimetic system.

2LQY の概要

• エントリーDOI: 10.2210/pdb2lqy/pdb
• NMR情報: BMRB: 18335
• 分子名称: Envelope glycoprotein H (1 entity in total)
• 機能のキーワード: viral protein
• 由来する生物種: Human herpesvirus 1 (HHV-1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2302.64

構造登録者

Isernia, C.,Galdiero, S.,Russo, L.,Falanga, A.,Cantisani, M.,Vitiello, M.,Fattorusso, R.,Malgieri, G.,Galdiero, M. (登録日: 2012-03-19, 公開日: 2012-04-25, 最終更新日: 2024-05-15)

主引用文献

Galdiero, S.,Russo, L.,Falanga, A.,Cantisani, M.,Vitiello, M.,Fattorusso, R.,Malgieri, G.,Galdiero, M.,Isernia, C.
Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System.
Biochemistry, 51:3121-3128, 2012

PubMed Abstract: Glycoprotein H (gH) of the herpes simplex virus type 1 is involved in the complex mechanism of membrane fusion of the viral envelope with host cells. The virus requires four glycoproteins (gB, gD, gH, gL) to execute fusion and the role played by gH remains mysterious. Mutational studies have revealed several regions of gH ectodomain required for fusion and identified the segment from amino acid 625 to 644 as the most fusogenic region. Here, we studied the behavior in a membrane-mimicking DPC micellar environment of a peptide encompassing this region (gH625-644) and determined its NMR solution structure and its orientation within the micelles.

PubMed: 22397737
DOI: 10.1021/bi201589m

実験手法

SOLUTION NMR