2LPV

Solution Structure of FKBP12 from Aedes aegypti

2LPV の概要

• エントリーDOI: 10.2210/pdb2lpv/pdb
• NMR情報: BMRB: 18278
• 分子名称: FKBP-type peptidyl-prolyl cis-trans isomerase (1 entity in total)
• 機能のキーワード: fkbp12, isomerase
• 由来する生物種: Aedes aegypti (Yellowfever mosquito)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11553.06

構造登録者

Chakraborty, G.,Shin, J. (登録日: 2012-02-20, 公開日: 2013-02-06, 最終更新日: 2024-05-15)

主引用文献

Chakraborty, G.,Shin, J.,Nguyen, Q.T.,Harikishore, A.,Baek, K.,Yoon, H.S.
Solution structure of FK506-binding protein 12 from Aedes aegypti.
Proteins, 80:2476-2481, 2012

PubMed Abstract: Dengue remains one of the major public concerns as the virus eludes the immune response. Currently, no vaccines or antiviral therapeutics are available for dengue prevention or treatment. Immunosuppressive drug FK506 shows an antimalarial activity, and its molecular target, FK506-binding protein (FKBP), was identified in human Plasmodium parasites. Likewise, a conserved FKBP family protein has also been identified in Aedes aegypti (AaFKBP12), which is expected to play a similar role in the life cycle of Aedes aegypti, the primary vector of dengue virus infection. As FKBPs belong to a highly conserved class of immunophilin family and are involved in key biological regulations, they are considered as attractive pharmacological targets. In this study, we have determined the nuclear magnetic resonance solution structure of AaFKBP12, a novel FKBP member from Aedes aegypti, and presented its structural features, which may facilitate the design of potential inhibitory ligands against the dengue-transmitting mosquitoes.

PubMed: 22806993
DOI: 10.1002/prot.24146

実験手法

SOLUTION NMR