2LP1

The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99)

2LP1 の概要

• エントリーDOI: 10.2210/pdb2lp1/pdb
• NMR情報: BMRB: 15775
• 分子名称: C99 (1 entity in total)
• 機能のキーワード: amyloid precursor protein c-terminal fragment, alzheimer's disease, membrane protein, amyloid-beta precursor, transmembrane protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13801.77

構造登録者

Barrett, P.J.,Song, Y.,Van Horn, W.D.,Hustedt, E.J.,Schafer, J.M.,Hadziselimovic, A.,Beel, A.J.,Sanders, C.R. (登録日: 2012-01-30, 公開日: 2012-06-06, 最終更新日: 2012-06-20)

• 主引用文献: Barrett, P.J.,Song, Y.,Van Horn, W.D.,Hustedt, E.J.,Schafer, J.M.,Hadziselimovic, A.,Beel, A.J.,Sanders, C.R.; The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.; Science, 336:1168-1171, 2012; PubMed: 22654059; DOI: 10.1126/science.1219988

実験手法

SOLUTION NMR