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2LNZ

Solution structure of the Get5 carboxyl domain from S. cerevisiae

2LNZ の概要
エントリーDOI10.2210/pdb2lnz/pdb
関連するPDBエントリー2LO0 3VEJ
NMR情報BMRB: 18186
分子名称Ubiquitin-like protein MDY2 (1 entity in total)
機能のキーワードdimerization, homodimerization, protein binding
由来する生物種Saccharomyces cerevisiae (Baker's yeast)
細胞内の位置Cytoplasm, cytosol: Q12285
タンパク質・核酸の鎖数2
化学式量合計14247.78
構造登録者
Chartron, J.W.,Vandervelde, D.G.,Rao, M.,Clemons Jr., W.M. (登録日: 2012-01-08, 公開日: 2012-01-25, 最終更新日: 2024-05-15)
主引用文献Chartron, J.W.,Vandervelde, D.G.,Rao, M.,Clemons, W.M.
Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex.
J.Biol.Chem., 287:8310-8317, 2012
Cited by
PubMed Abstract: Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. Get5 forms a homodimer mediated by its carboxyl domain. We show here that a conserved motif exists within the carboxyl domain. A high resolution crystal structure and solution NMR structures of this motif reveal a novel and stable helical dimerization domain. We additionally determined a solution NMR structure of a divergent fungal homolog, and comparison of these structures allows annotation of specific stabilizing interactions. Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex.
PubMed: 22262836
DOI: 10.1074/jbc.M111.333252
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 2lnz
検証レポート(詳細版)ダウンロードをダウンロード

238582

件を2025-07-09に公開中

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