2LNA

Solution NMR Structure of the mitochondrial inner membrane domain (residues 164-251), FtsH_ext, from the paraplegin-like protein AFG3L2 from Homo sapiens, Northeast Structural Genomics Consortium Target HR6741A

2LNA の概要

• エントリーDOI: 10.2210/pdb2lna/pdb
• NMR情報: BMRB: 18156
• 分子名称: AFG3-like protein 2 (1 entity in total)
• 機能のキーワード: structural genomics, northeast structural genomics consortium (nesg), psi-biology, protein structure initiative, mpp, hydrolase, mitochondrial protein partnership
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion membrane; Multi-pass membrane protein: Q9Y4W6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11493.87

構造登録者

Ramelot, T.A.,Yang, Y.,Lee, H.,Janua, H.,Kohan, E.,Shastry, R.,Acton, T.B.,Xiao, R.,Everett, J.K.,Prestegard, J.H.,Montelione, G.T.,Kennedy, M.A.,Northeast Structural Genomics Consortium (NESG),Mitochondrial Protein Partnership (MPP) (登録日: 2011-12-20, 公開日: 2012-01-25, 最終更新日: 2024-05-15)

主引用文献

Ramelot, T.A.,Yang, Y.,Sahu, I.D.,Lee, H.W.,Xiao, R.,Lorigan, G.A.,Montelione, G.T.,Kennedy, M.A.
NMR structure and MD simulations of the AAA protease intermembrane space domain indicates peripheral membrane localization within the hexaoligomer.
Febs Lett., 587:3522-3528, 2013

PubMed Abstract: We have determined the solution NMR structure of the intermembrane space domain (IMSD) of the human mitochondrial ATPase associated with various activities (AAA) protease known as AFG3-like protein 2 (AFG3L2). Our structural analysis and molecular dynamics results indicate that the IMSD is peripherally bound to the membrane surface. This is a modification to the location of the six IMSDs in a model of the full length yeast hexaoligomeric homolog of AFG3L2 determined at low resolution by electron cryomicroscopy [1]. The predicted protein-protein interaction surface, located on the side furthest from the membrane, may mediate binding to substrates as well as prohibitins.

PubMed: 24055473
DOI: 10.1016/j.febslet.2013.09.009

実験手法

SOLUTION NMR