2LMA
Solution structure of CD4+ T cell derived peptide Thp5
Summary for 2LMA
| Entry DOI | 10.2210/pdb2lma/pdb |
| NMR Information | BMRB: 17584 |
| Descriptor | Thp5 peptide (1 entity in total) |
| Functional Keywords | thp5, cd4+, immune system |
| Total number of polymer chains | 1 |
| Total formula weight | 2693.01 |
| Authors | Pandey, N.K.,Khan, M.M.,Chatterjee, S.,Dwivedi, V.P.,Tousif, S.,Das, J.,Van Kaer, L. (deposition date: 2011-11-29, release date: 2011-12-28, Last modification date: 2024-05-15) |
| Primary citation | Khan, M.M.,Chatterjee, S.,Dwivedi, V.P.,Pandey, N.K.,Singh, Y.,Tousif, S.,Bhavesh, N.S.,Van Kaer, L.,Das, J.,Das, G. CD4+ T cell derived novel peptide Thp5 induces IL-4 production in CD4+ T cells to direct T helper 2 cell differentiation J.Biol.Chem., 2011 Cited by PubMed Abstract: The differentiation of naïve CD4(+) T cells into T helper 2 (Th2) cells requires production of the cytokine IL-4 in the local microenvironment. It is evident that naïve/quiescently activated CD4(+) T cells produce the IL-4 that drives Th2 cell differentiation. Because early production of IL-4 in naïve T cells leads to preferential Th2 cell differentiation, this process needs to be tightly regulated so as to avoid catastrophic and misdirected Th2 cell differentiation. Here, we show that Thp5, a novel peptide with structural similarity to vasoactive intestinal peptide, regulates production of early IL-4 in newly activated CD4(+) T cells. Induction of IL-4 in CD4(+) T cells by Thp5 is independent of the transcription factor STAT6 but dependent on ERK1/2 signaling. Furthermore, cytokines (IL-12 and TGF-β) that promote the differentiation of Th1 or Th17 cells inhibit Thp5 induction, thus suppressing Th2 cell differentiation. We further showed that Thp5 enhances Th2 responses and exacerbates allergic airway inflammation in mice. Taken together, our findings reveal that early activated CD4(+) T cells produce Thp5, which plays a critical role as a molecular switch in the differentiation of Th cells, biasing the response toward the Th2 cell phenotype. PubMed: 22130674DOI: 10.1074/jbc.M111.319947 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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