2LMA

Solution structure of CD4+ T cell derived peptide Thp5

2LMA の概要

• エントリーDOI: 10.2210/pdb2lma/pdb
• NMR情報: BMRB: 17584
• 分子名称: Thp5 peptide (1 entity in total)
• 機能のキーワード: thp5, cd4+, immune system
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2693.01

構造登録者

Pandey, N.K.,Khan, M.M.,Chatterjee, S.,Dwivedi, V.P.,Tousif, S.,Das, J.,Van Kaer, L. (登録日: 2011-11-29, 公開日: 2011-12-28, 最終更新日: 2024-05-15)

主引用文献

Khan, M.M.,Chatterjee, S.,Dwivedi, V.P.,Pandey, N.K.,Singh, Y.,Tousif, S.,Bhavesh, N.S.,Van Kaer, L.,Das, J.,Das, G.
CD4+ T cell derived novel peptide Thp5 induces IL-4 production in CD4+ T cells to direct T helper 2 cell differentiation
J.Biol.Chem., 2011

PubMed Abstract: The differentiation of naïve CD4(+) T cells into T helper 2 (Th2) cells requires production of the cytokine IL-4 in the local microenvironment. It is evident that naïve/quiescently activated CD4(+) T cells produce the IL-4 that drives Th2 cell differentiation. Because early production of IL-4 in naïve T cells leads to preferential Th2 cell differentiation, this process needs to be tightly regulated so as to avoid catastrophic and misdirected Th2 cell differentiation. Here, we show that Thp5, a novel peptide with structural similarity to vasoactive intestinal peptide, regulates production of early IL-4 in newly activated CD4(+) T cells. Induction of IL-4 in CD4(+) T cells by Thp5 is independent of the transcription factor STAT6 but dependent on ERK1/2 signaling. Furthermore, cytokines (IL-12 and TGF-β) that promote the differentiation of Th1 or Th17 cells inhibit Thp5 induction, thus suppressing Th2 cell differentiation. We further showed that Thp5 enhances Th2 responses and exacerbates allergic airway inflammation in mice. Taken together, our findings reveal that early activated CD4(+) T cells produce Thp5, which plays a critical role as a molecular switch in the differentiation of Th cells, biasing the response toward the Th2 cell phenotype.

PubMed: 22130674
DOI: 10.1074/jbc.M111.319947

実験手法

SOLUTION NMR