2LDX

CHARACTERIZATION OF THE ANTIGENIC SITES ON THE REFINED 3-ANGSTROMS RESOLUTION STRUCTURE OF MOUSE TESTICULAR LACTATE DEHYDROGENASE C4

「1LDX」から置き換えられました

2LDX の概要

• エントリーDOI: 10.2210/pdb2ldx/pdb
• 分子名称: APO-LACTATE DEHYDROGENASE (2 entities in total)
• 機能のキーワード: oxidoreductase(choh(d)-nad(a))
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm: P00342
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 143466.42

構造登録者

Griffith, J.P.,Rossmann, M.G. (登録日: 1987-11-25, 公開日: 1989-04-19, 最終更新日: 2023-09-06)

主引用文献

Hogrefe, H.H.,Griffith, J.P.,Rossmann, M.G.,Goldberg, E.
Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4.
J.Biol.Chem., 262:13155-13162, 1987

PubMed Abstract: The atomic structure of mouse testicular apolactate dehydrogenase C4 has been refined to 3.0-A resolution yielding a final crystallographic R-factor of 0.256. Comparison with the refined structure of dogfish apolactate dehydrogenase A4 shows that equivalent secondary structure elements are essentially in the same position relative to the molecular 2-fold axes, except for the helices alpha D, alpha E, and alpha 2G in the vicinity of the active center, and the carboxyl-terminal helix alpha H. The positions of antigenic peptides correlate best with surface accessibilities of the monomer rather than of the full tetrameric molecule.

PubMed: 2443489

実験手法

X-RAY DIFFRACTION (2.96 Å)