2LAT

Solution structure of a Human minimembrane protein OST4

2LAT の概要

• エントリーDOI: 10.2210/pdb2lat/pdb
• NMR情報: BMRB: 17537
• 分子名称: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 (1 entity in total)
• 機能のキーワード: membrane protein, oligosaccharyltransferase, integral membrane protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass membrane protein (Potential): P0C6T2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4196.00

構造登録者

Gayen, S.,Kang, C. (登録日: 2011-03-21, 公開日: 2011-06-29, 最終更新日: 2024-05-15)

主引用文献

Gayen, S.,Kang, C.
Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex.
Biochem.Biophys.Res.Commun., 409:572-576, 2011

PubMed Abstract: Oligosaccharyltransferase (OST) is a membrane associated enzyme complex that mediates transfer of an oligosaccharide onto asparagine residue of a protein. Human Ost4 is a small membrane protein and belongs to one of the seven subunits of human OST. This study determined the solution structure of human Ost4 in solvent system using NMR spectroscopy. Ost4 was demonstrated that the residues 5-30 adopt an α-helical structure. A kink structure was observed in the transmembrane domain, which may be important for its function.

PubMed: 21609714
DOI: 10.1016/j.bbrc.2011.05.050

実験手法

SOLUTION NMR