2L9I

NMR structure of thymosin alpha-1

2L9I の概要

• エントリーDOI: 10.2210/pdb2l9i/pdb
• NMR情報: BMRB: 17458
• 分子名称: Thymosin alpha-1 (1 entity in total)
• 機能のキーワード: lymphocyte membrane binding peptide, t-cell differentiation, immunopotentiation, transcription, peptide binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P06454
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3096.31

構造登録者

Elizondo-Riojas, M.A.,Gorenstein, D.G.,Volk, D.E. (登録日: 2011-02-11, 公開日: 2011-12-28, 最終更新日: 2024-11-27)

主引用文献

Elizondo-Riojas, M.A.,Chamow, S.M.,Tuthill, C.W.,Gorenstein, D.G.,Volk, D.E.
NMR structure of human thymosin alpha-1.
Biochem.Biophys.Res.Commun., 416:356-361, 2011

PubMed Abstract: 800 MHz NMR structure of the 28-residue peptide thymosin alpha-1 in 40% TFE/60% water (v/v) has been determined. Restrained molecular dynamic simulations with an explicit solvent box containing 40% TFE/60% TIP3P water (v/v) were used, in order to get the 3D model of the NMR structure. We found that the peptide adopts a structured conformation having two stable regions: an alpha-helix region from residues 14 to 26 and two double β-turns in the N-terminal twelve residues which form a distorted helical structure.

PubMed: 22115779
DOI: 10.1016/j.bbrc.2011.11.041

実験手法

SOLUTION NMR