2L6K

Solution Structure of a Nonphosphorylated Peptide Recognizing Domain

Summary for 2L6K

• Entry DOI: 10.2210/pdb2l6k/pdb
• NMR Information: BMRB: 17314
• Descriptor: Tensin-like C1 domain-containing phosphatase (1 entity in total)
• Functional Keywords: antitumor protein, cell adhesion, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 13687.78

Authors

Dai, K.,Liao, S.,Zhang, J.,Zhang, X.,Tu, X. (deposition date: 2010-11-22, release date: 2011-10-12, Last modification date: 2024-05-15)

Primary citation

Dai, K.,Liao, S.,Zhang, J.,Zhang, X.,Tu, X.
Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1
Plos One, 6:e21965-e21965, 2011

PubMed Abstract: Src homology 2 (SH2) domain is a conserved module involved in various biological processes. Tensin family member was reported to be involved in tumor suppression by interacting with DLC-1 (deleted-in-liver-cancer-1) via its SH2 domain. We explore here the important questions that what the structure of tensin2 SH2 domain is, and how it binds to DLC-1, which might reveal a novel binding mode.

PubMed: 21765928
DOI: 10.1371/journal.pone.0021965

Experimental method

SOLUTION NMR