2L6K

Solution Structure of a Nonphosphorylated Peptide Recognizing Domain

2L6K の概要

• エントリーDOI: 10.2210/pdb2l6k/pdb
• NMR情報: BMRB: 17314
• 分子名称: Tensin-like C1 domain-containing phosphatase (1 entity in total)
• 機能のキーワード: antitumor protein, cell adhesion, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13687.78

構造登録者

Dai, K.,Liao, S.,Zhang, J.,Zhang, X.,Tu, X. (登録日: 2010-11-22, 公開日: 2011-10-12, 最終更新日: 2024-05-15)

主引用文献

Dai, K.,Liao, S.,Zhang, J.,Zhang, X.,Tu, X.
Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1
Plos One, 6:e21965-e21965, 2011

PubMed Abstract: Src homology 2 (SH2) domain is a conserved module involved in various biological processes. Tensin family member was reported to be involved in tumor suppression by interacting with DLC-1 (deleted-in-liver-cancer-1) via its SH2 domain. We explore here the important questions that what the structure of tensin2 SH2 domain is, and how it binds to DLC-1, which might reveal a novel binding mode.

PubMed: 21765928
DOI: 10.1371/journal.pone.0021965

実験手法

SOLUTION NMR