2L6I
Solution structure of coronaviral stem-loop 2 (SL2)
Summary for 2L6I
| Entry DOI | 10.2210/pdb2l6i/pdb |
| NMR Information | BMRB: 17309 |
| Descriptor | RNA (5'-R(*GP*AP*UP*CP*UP*CP*UP*UP*GP*UP*AP*GP*AP*UP*CP*A)-3') (1 entity in total) |
| Functional Keywords | rna tetraloop, severe acute respiratory syndrome, mouse hepatitis virus, coronavirus, rna |
| Total number of polymer chains | 1 |
| Total formula weight | 5060.02 |
| Authors | Lee, C.,Li, L.,Giedroc, D.P. (deposition date: 2010-11-21, release date: 2011-03-23, Last modification date: 2024-05-01) |
| Primary citation | Lee, C.W.,Li, L.,Giedroc, D.P. The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold. Febs Lett., 585:1049-1053, 2011 Cited by PubMed Abstract: The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed. PubMed: 21382373DOI: 10.1016/j.febslet.2011.03.002 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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