2L63

NMR solution structure of GLP-2 in 2,2,2 trifluroethanol

2L63 の概要

• エントリーDOI: 10.2210/pdb2l63/pdb
• 関連するPDBエントリー: 2L64
• NMR情報: BMRB: 17296
• 分子名称: Glucagon-like peptide 2 (1 entity in total)
• 機能のキーワード: glp-2, hormone, gpcr, docking, small bowel syndrome
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P01275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3769.14

構造登録者

Venneti, K.C.,Hewage, C.M. (登録日: 2010-11-12, 公開日: 2011-02-23, 最終更新日: 2024-05-01)

主引用文献

Venneti, K.C.,Hewage, C.M.
Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.
Febs Lett., 585:346-352, 2011

PubMed Abstract: Glucagon-like peptide-2 (GLP-2) is a therapeutic target used in the treatment of short bowel syndrome. In this paper, we present the three dimensional solution structure of GLP-2 peptide determined using nuclear magnetic resonance (NMR) and molecular modelling. The GLP-2 adopts an α-helical conformation similar to that of secretin family of hormones. In order to understand the molecular details governing the ligand binding and receptor activation, macromolecular docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone using a data driven docking program.

PubMed: 21167157
DOI: 10.1016/j.febslet.2010.12.011

実験手法

SOLUTION NMR