2L5X

Solution structure of IL1A-S100A13 complex

2L5X の概要

• エントリーDOI: 10.2210/pdb2l5x/pdb
• 分子名称: Interleukin-1 alpha, Protein S100-A13 (2 entities in total)
• 機能のキーワード: protein-protein complex, key component in non-classical pathway of il-1a, interleukin-1alpha, s100a13, cytokine-transport protein complex, cytokine/transport protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01583; Cytoplasm: Q99584
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57435.50

構造登録者

Mohan, S.K.,Yu, C. (登録日: 2010-11-09, 公開日: 2011-01-26, 最終更新日: 2024-05-01)

主引用文献

Mohan, S.K.,Yu, C.
The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion
J.Biol.Chem., 286:14608-14617, 2011

PubMed Abstract: Interleukin 1α (IL1α) plays an important role in several key biological functions, such as angiogenesis, cell proliferation, and tumor growth in several types of cancer. IL1α is a potent cytokine that induces a wide spectrum of immunological and inflammatory activities. The biological effects of IL1α are mediated through the activation of transmembrane receptors (IL1Rs) and therefore require the release of the protein into the extracellular space. IL1α is exported through a non-classical release pathway involving the formation of a specific multiprotein complex, which includes IL1α and S100A13. Because IL1α plays an important role in cell proliferation and angiogenesis, inhibiting the formation of the IL1α-S100A13 complex would be an effective strategy to inhibit a wide range of cancers. To understand the molecular events in the IL1α release pathway, we studied the structure of the IL1α-S100A13 tetrameric complex, which is the key complex formed during the non-classical pathway of IL1α release.

PubMed: 21270123
DOI: 10.1074/jbc.M110.201954

実験手法

SOLUTION NMR