2L3R

NMR structure of UHRF1 Tandem Tudor Domains in a complex with Histone H3 peptide

2L3R の概要

• エントリーDOI: 10.2210/pdb2l3r/pdb
• NMR情報: BMRB: 17200
• 分子名称: E3 ubiquitin-protein ligase UHRF1, Histone H3 (2 entities in total)
• 機能のキーワード: tudor domain, heterochromatin, transcriptional repression, structural genomics, structural genomics consortium, sgc, dna binding protein, dna binding protein-gene regulation complex, dna binding protein/gene regulation
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20174.53

構造登録者

Nady, N.,Lemak, A.,Fares, C.,Gutmanas, A.,Avvakumov, G.,Xue, S.,Arrowsmith, C.,Structural Genomics Consortium (SGC) (登録日: 2010-09-21, 公開日: 2011-04-13, 最終更新日: 2020-02-05)

• 主引用文献: Nady, N.,Lemak, A.,Walker, J.R.,Avvakumov, G.V.,Kareta, M.S.,Achour, M.,Xue, S.,Duan, S.,Allali-Hassani, A.,Zuo, X.,Wang, Y.X.,Bronner, C.,Chedin, F.,Arrowsmith, C.H.,Dhe-Paganon, S.; Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein.; J.Biol.Chem., 286:24300-24311, 2011; PubMed: 21489993; DOI: 10.1074/jbc.M111.234104

実験手法

SOLUTION NMR