2KXW
Structure of the C-domain Fragment of apo Calmodulin Bound to the IQ motif of Nav1.2
Summary for 2KXW
| Entry DOI | 10.2210/pdb2kxw/pdb |
| Descriptor | Calmodulin, Sodium channel protein type 2 subunit alpha (2 entities in total) |
| Functional Keywords | action potential, amino acid motifs, animals, autism, biomolecular, brain chemistry, calcium-binding proteins, calmodulin, channel, glutamine, humans, ion channel gating, isoleucine, iq motif, metal transport, models, molecular, nav1.2, neuronal, peptides, protein binding, protein structure, sodium channels, tertiary, tyrosine, voltage-dependent, voltage gated, calcium-binding protein-metal transport complex, calcium-binding protein/metal transport |
| Biological source | Paramecium tetraurelia More |
| Cellular location | Membrane; Multi-pass membrane protein: P04775 |
| Total number of polymer chains | 2 |
| Total formula weight | 11786.40 |
| Authors | Feldkamp, M.D.,Yu, L.,Shea, M.A. (deposition date: 2010-05-13, release date: 2011-04-13, Last modification date: 2011-07-13) |
| Primary citation | Feldkamp, M.D.,Yu, L.,Shea, M.A. Structural and Energetic Determinants of Apo Calmodulin Binding to the IQ Motif of the Na(V)1.2 Voltage-Dependent Sodium Channel. Structure, 19:733-747, 2011 Cited by PubMed: 21439835DOI: 10.1016/j.str.2011.02.009 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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