2KWT

Solution structure of NS2 [27-59]

2KWT の概要

• エントリーDOI: 10.2210/pdb2kwt/pdb
• 関連するPDBエントリー: 1JY0
• NMR情報: BMRB: 16886
• 分子名称: Protease NS2-3 (1 entity in total)
• 機能のキーワード: hepatitis c virus, ns2 domain, membrane protein, viral protein
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q9WMX2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4054.85

構造登録者

Montserret, R.,Bartenschlager, R.,Penin, F. (登録日: 2010-04-19, 公開日: 2011-03-02, 最終更新日: 2024-05-01)

• 主引用文献: Jirasko, V.,Montserret, R.,Lee, J.Y.,Gouttenoire, J.,Moradpour, D.,Penin, F.,Bartenschlager, R.; Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.; Plos Pathog., 6:e1001233-e1001233, 2010; PubMed: 21187906; DOI: 10.1371/journal.ppat.1001233

実験手法

SOLUTION NMR