2KWL

Solution Structure of acyl carrier protein from Borrelia burgdorferi

2KWL の概要

• エントリーDOI: 10.2210/pdb2kwl/pdb
• NMR情報: BMRB: 16856
• 分子名称: Acyl carrier protein (1 entity in total)
• 機能のキーワード: acyl carrier protein, structural genomics, seattle structural genomics center for infectious disease, ssgcid, lipid binding protein
• 由来する生物種: Borrelia burgdorferi (Lyme disease spirochete)
• 細胞内の位置: Cytoplasm (By similarity): O51647
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9642.56

構造登録者

Barnwal, R.,Vittal, V.,Moody, J.,Varani, G.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2010-04-12, 公開日: 2010-04-28, 最終更新日: 2024-05-01)

主引用文献

Barnwal, R.P.,Van Voorhis, W.C.,Varani, G.
NMR structure of an acyl-carrier protein from Borrelia burgdorferi.
Acta Crystallogr.,Sect.F, 67:1137-1140, 2011

PubMed Abstract: Nearly complete resonance assignment and the high-resolution NMR structure of the acyl-carrier protein from Borrelia burgdorferi, a target of the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure-determination pipeline, are reported. This protein was chosen as a potential target for drug-discovery efforts because of its involvement in fatty-acid biosynthesis, an essential metabolic pathway, in bacteria. It was possible to assign >98% of backbone resonances and >92% of side-chain resonances using multidimensional NMR spectroscopy. The NMR structure was determined to a backbone r.m.s.d. of 0.4 Å and contained four α-helices and two 3(10)-helices. A structure-homology search revealed that this protein is highly similar to the acyl-carrier protein from Aquifex aeolicus.

PubMed: 21904063
DOI: 10.1107/S1744309111004386

実験手法

SOLUTION NMR