2KVM

Solution structure of the CBX7 chromodomain in complex with a H3K27me2 peptide

2KVM の概要

• エントリーDOI: 10.2210/pdb2kvm/pdb
• NMR情報: BMRB: 16778
• 分子名称: Chromobox protein homolog 7, histone H3 peptide (residues 15-30) with dimethylated lysine 27 (2 entities in total)
• 機能のキーワード: histone modification, lysine methylation, chromobox, polycomb, chromatin-binding, chromatin regulator, nucleus, repressor, transcription, transcription regulation
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10564.22

構造登録者

Yap, K.L.,Zeng, L.,Zhou, M. (登録日: 2010-03-17, 公開日: 2010-06-30, 最終更新日: 2020-02-05)

• 主引用文献: Yap, K.L.,Li, S.,Munoz-Cabello, A.M.,Raguz, S.,Zeng, L.,Mujtaba, S.,Gil, J.,Walsh, M.J.,Zhou, M.M.; Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.; Mol.Cell, 38:662-674, 2010; PubMed: 20541999; DOI: 10.1016/j.molcel.2010.03.021

実験手法

SOLUTION NMR