2KV6

Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether

2KV6 の概要

• エントリーDOI: 10.2210/pdb2kv6/pdb
• 分子名称: 5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3', 5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3', KWKK Tetrapeptide (3 entities in total)
• 機能のキーワード: dna-peptide conjugate, trimethylene, acrolein-dg adduct, dna-peptide complex, dna binding protein-dna complex, dna binding protein/dna
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 7960.63

構造登録者

Huang, H.,Kozekov, I.D.,Kozekova, A.,Rizzo, C.J.,McCullough, A.,LLoyd, R.S.,Stone, M.P. (登録日: 2010-03-08, 公開日: 2010-07-21, 最終更新日: 2011-07-13)

• 主引用文献: Huang, H.,Kozekov, I.D.,Kozekova, A.,Rizzo, C.J.,McCullough, A.K.,Lloyd, R.S.,Stone, M.P.; Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-gamma-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage .; Biochemistry, 49:6155-6164, 2010; PubMed: 20604523; DOI: 10.1021/bi100364f

実験手法

SOLUTION NMR