2KUG
Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain
Summary for 2KUG
Entry DOI | 10.2210/pdb2kug/pdb |
Related | 2KUH |
NMR Information | BMRB: 16764 |
Descriptor | Calmodulin-1, CALCIUM ION, 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE (3 entities in total) |
Functional Keywords | calmodulin, calcium binding, volatile anesthetic, halothane, cytoskeleton, isopeptide bond, methylation, phosphoprotein, metal binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16998.89 |
Authors | Juranic, N.,Macura, S.,Simeonov, M.V.,Jones, K.A.,Penheiter, A.R.,Hock, T.J.,Streiff, J.H. (deposition date: 2010-02-17, release date: 2010-03-09, Last modification date: 2024-05-01) |
Primary citation | Juranic, N.O.,Jones, K.A.,Penheiter, A.R.,Hock, T.J.,Streiff, J.H. Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase. J. Serb. Chem. Soc., 78:1655-1670, 2013 |
Experimental method | SOLUTION NMR |
Structure validation
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