2KQM

Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain

Summary for 2KQM

• Entry DOI: 10.2210/pdb2kqm/pdb
• Related: 2KQN
• NMR Information: BMRB: 16606
• Descriptor: Ig kappa chain V-I region AU (1 entity in total)
• Functional Keywords: amyloidosis, immunoglobulin kappa light chain, homodimer, bence-jones protein, disulfide bond, immunoglobulin domain, immunoglobulin v region, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 24206.57

Authors

Volkman, B.F.,Peterson, F.C.,Ramirez-Alvarado, M.,Baden, E.M. (deposition date: 2009-11-11, release date: 2010-03-16, Last modification date: 2011-07-13)

• Primary citation: Peterson, F.C.,Baden, E.M.,Owen, B.A.,Volkman, B.F.,Ramirez-Alvarado, M.; A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface.; Structure, 18:563-570, 2010; PubMed: 20462490; DOI: 10.1016/j.str.2010.02.012

Experimental method

SOLUTION NMR