2KPY

Solution Structure of the major allergen of Artemisia vulgaris (Art v 1)

2KPY の概要

• エントリーDOI: 10.2210/pdb2kpy/pdb
• NMR情報: BMRB: 16111
• 分子名称: Major pollen allergen Art v 1 (1 entity in total)
• 機能のキーワード: defensin-like, poly-proline, allergen
• 由来する生物種: Artemisia vulgaris (common wormwood)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10816.04

構造登録者

Razzera, G.,Gadermaier, G.,Almeida, M.,Egger, M.,Jahn-Schmid, B.,Almeida, F.,Ferreira, F.,Valente, A. (登録日: 2009-10-23, 公開日: 2010-10-06, 最終更新日: 2024-11-06)

主引用文献

Razzera, G.,Gadermaier, G.,de Paula, V.,Almeida, M.S.,Egger, M.,Jahn-Schmid, B.,Almeida, F.C.,Ferreira, F.,Valente, A.P.
Mapping the interactions between a major pollen allergen and human IgE antibodies.
Structure, 18:1011-1021, 2010

PubMed Abstract: The interaction of specific IgE antibodies with allergens is a key event in the induction of allergic symptoms, thus representing an important target for therapeutic interventions in Type I allergies. We report here the solution NMR structure of Art v 1, the major mugwort pollen allergen. Art v 1 is the first protein structure with an allergenic defensin fold linked to a polyproline domain, which has not been identified in any reported allergen structure in the PDB. Moreover, the direct interaction of polyclonal IgE antibodies from an allergic patient has been mapped on the surface of an allergen for the first time. The data presented herein provide the basis for the design of tools for safe and effective vaccination against mugwort pollen allergy.

PubMed: 20696401
DOI: 10.1016/j.str.2010.05.012

実験手法

SOLUTION NMR