2KMS
Combined high- and low-resolution techniques reveal compact structure in central portion of factor H despite long inter-modular linkers
Summary for 2KMS
Entry DOI | 10.2210/pdb2kms/pdb |
NMR Information | BMRB: 16439 |
Descriptor | Complement factor H (1 entity in total) |
Functional Keywords | compact structure, limited interdomain flexibility, age-related macular degeneration, alternative splicing, complement alternate pathway, disease mutation, disulfide bond, glycoprotein, immune response, innate immunity, polymorphism, secreted, sushi, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 13262.05 |
Authors | Schmidt, C.Q.,Herbert, A.P.,Guariento, M.,Mertens, H.D.T.,Soares, D.C.,Uhrin, D.,Rowe, A.J.,Svergun, D.I.,Barlow, P.N. (deposition date: 2009-08-04, release date: 2009-11-03, Last modification date: 2020-02-26) |
Primary citation | Schmidt, C.Q.,Herbert, A.P.,Mertens, H.D.T.,Guariento, M.,Soares, D.C.,Uhrin, D.,Rowe, A.J.,Svergun, D.I.,Barlow, P.N. The Central Portion of Factor H (Modules 10-15) Is Compact and Contains a Structurally Deviant CCP Module J.Mol.Biol., 395:105-122, 2010 Cited by PubMed: 19835885DOI: 10.1016/j.jmb.2009.10.010 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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