2KMS

Combined high- and low-resolution techniques reveal compact structure in central portion of factor H despite long inter-modular linkers

2KMS の概要

• エントリーDOI: 10.2210/pdb2kms/pdb
• NMR情報: BMRB: 16439
• 分子名称: Complement factor H (1 entity in total)
• 機能のキーワード: compact structure, limited interdomain flexibility, age-related macular degeneration, alternative splicing, complement alternate pathway, disease mutation, disulfide bond, glycoprotein, immune response, innate immunity, polymorphism, secreted, sushi, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13262.05

構造登録者

Schmidt, C.Q.,Herbert, A.P.,Guariento, M.,Mertens, H.D.T.,Soares, D.C.,Uhrin, D.,Rowe, A.J.,Svergun, D.I.,Barlow, P.N. (登録日: 2009-08-04, 公開日: 2009-11-03, 最終更新日: 2020-02-26)

• 主引用文献: Schmidt, C.Q.,Herbert, A.P.,Mertens, H.D.T.,Guariento, M.,Soares, D.C.,Uhrin, D.,Rowe, A.J.,Svergun, D.I.,Barlow, P.N.; The Central Portion of Factor H (Modules 10-15) Is Compact and Contains a Structurally Deviant CCP Module; J.Mol.Biol., 395:105-122, 2010; PubMed: 19835885; DOI: 10.1016/j.jmb.2009.10.010

実験手法

SOLUTION NMR