2KIB

Protein Fibril

2KIB の概要

• エントリーDOI: 10.2210/pdb2kib/pdb
• 関連するPDBエントリー: 2g48 3dgj
• NMR情報: BMRB: 20074
• 分子名称: NFGAIL segment from human islet amyloid polypeptide (1 entity in total)
• 機能のキーワード: protein fibril, iapp, amylin, snnfgailss, symmetry
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 5766.52

構造登録者

Nielsen, J.T.,Bjerring, M.,Jeppesen, M.D.,Pedersen, R.O.,Pedersen, J.M.,Hein, K.L.,Vosegaard, T.,Skrydstrup, T.,Otzen, D.E.,Nielsen, N. (登録日: 2009-05-01, 公開日: 2009-09-08, 最終更新日: 2024-05-01)

主引用文献

Nielsen, J.T.,Bjerring, M.,Jeppesen, M.D.,Pedersen, R.O.,Pedersen, J.M.,Hein, K.L.,Vosegaard, T.,Skrydstrup, T.,Otzen, D.E.,Nielsen, N.C.
Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy.
Angew.Chem.Int.Ed.Engl., 48:2118-2121, 2009

PubMed Abstract: The fibril structure formed by the amyloidogenic fragment SNNFGAILSS of the human islet amyloid polypeptide (hIAPP) is determined with 0.52 A resolution. Symmetry information contained in the easily obtainable resonance assignments from solid-state NMR spectra (see picture), along with long-range constraints, can be applied to uniquely identify the supramolecular organization of fibrils.

PubMed: 19130518
DOI: 10.1002/anie.200804198

実験手法

SOLID-STATE NMR