2KI5

HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION

Replaces:  1KI5

Summary for 2KI5

• Entry DOI: 10.2210/pdb2ki5/pdb
• Descriptor: PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-HYROXYETHOXYMETHYLGUANINE, ... (4 entities in total)
• Functional Keywords: transferase (phosphotransferase) thymid, transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir), transferase
• Biological source: Human herpesvirus 1 (Herpes simplex virus type 1)
• Total number of polymer chains: 2
• Total formula weight: 80367.68

Authors

Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. (deposition date: 1999-02-12, release date: 1999-03-04, Last modification date: 2023-08-30)

• Primary citation: Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R.; Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.; FEBS Lett., 443:121-125, 1999; PubMed: 9989588; DOI: 10.1016/S0014-5793(98)01619-6

Experimental method

X-RAY DIFFRACTION (1.9 Å)