2KI5
HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Replaces: 1KI5Summary for 2KI5
Entry DOI | 10.2210/pdb2ki5/pdb |
Descriptor | PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-HYROXYETHOXYMETHYLGUANINE, ... (4 entities in total) |
Functional Keywords | transferase (phosphotransferase) thymid, transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir), transferase |
Biological source | Human herpesvirus 1 (Herpes simplex virus type 1) |
Total number of polymer chains | 2 |
Total formula weight | 80367.68 |
Authors | Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. (deposition date: 1999-02-12, release date: 1999-03-04, Last modification date: 2023-08-30) |
Primary citation | Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir. FEBS Lett., 443:121-125, 1999 Cited by PubMed: 9989588DOI: 10.1016/S0014-5793(98)01619-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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