2KI5

HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION

「1KI5」から置き換えられました

2KI5 の概要

• エントリーDOI: 10.2210/pdb2ki5/pdb
• 分子名称: PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-HYROXYETHOXYMETHYLGUANINE, ... (4 entities in total)
• 機能のキーワード: transferase (phosphotransferase) thymid, transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir), transferase
• 由来する生物種: Human herpesvirus 1 (Herpes simplex virus type 1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80367.68

構造登録者

Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R. (登録日: 1999-02-12, 公開日: 1999-03-04, 最終更新日: 2023-08-30)

• 主引用文献: Bennett, M.S.,Wien, F.,Champness, J.N.,Batuwangala, T.,Rutherford, T.,Summers, W.C.,Sun, H.,Wright, G.,Sanderson, M.R.; Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.; FEBS Lett., 443:121-125, 1999; PubMed: 9989588; DOI: 10.1016/S0014-5793(98)01619-6

実験手法

X-RAY DIFFRACTION (1.9 Å)