2KI0

NMR Structure of a de novo designed beta alpha beta

2KI0 の概要

• エントリーDOI: 10.2210/pdb2ki0/pdb
• 分子名称: DS119 (1 entity in total)
• 機能のキーワード: beta-alpha-beta, de novo protein
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4036.61

構造登録者

Liang, H.,Chen, H.,Fan, K.,Wei, P.,Guo, X.,Jin, C.,Zeng, C.,Tang, C.,Lai, L. (登録日: 2009-04-18, 公開日: 2009-10-20, 最終更新日: 2024-05-29)

主引用文献

Liang, H.,Chen, H.,Fan, K.,Wei, P.,Guo, X.,Jin, C.,Zeng, C.,Tang, C.,Lai, L.
De novo design of a beta alpha beta motif.
Angew.Chem.Int.Ed.Engl., 48:3301-3303, 2009

PubMed Abstract: A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.

PubMed: 19347908
DOI: 10.1002/anie.200805476

実験手法

SOLUTION NMR