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2KH2

Solution structure of a scFv-IL-1B complex

Summary for 2KH2
Entry DOI10.2210/pdb2kh2/pdb
DescriptorInterleukin-1 beta, scFv (2 entities in total)
Functional Keywordsscfv, single chain fv, il-1b, antibody, cytokine, inflammatory response, mitogen, pyrogen, secreted, cytokine-immune system complex, cytokine/immune system
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01584
Total number of polymer chains2
Total formula weight44789.14
Authors
Wilkinson, I.C.,Hall, C.J.,Veverka, V.,Muskett, F.W.,Stephens, P.E.,Taylor, R.J.,Henry, A.J.,Carr, M.D. (deposition date: 2009-03-23, release date: 2009-09-08, Last modification date: 2022-03-16)
Primary citationWilkinson, I.C.,Hall, C.J.,Veverka, V.,Shi, J.Y.,Muskett, F.W.,Stephens, P.E.,Taylor, R.J.,Henry, A.J.,Carr, M.D.
High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284:31928-31935, 2009
Cited by
PubMed: 19776018
DOI: 10.1074/jbc.M109.025304
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

217705

数据于2024-03-27公开中

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