2KGU
Spatial structure of purotoxin-1 in water
Summary for 2KGU
| Entry DOI | 10.2210/pdb2kgu/pdb |
| Descriptor | Purotoxin-1 (1 entity in total) |
| Functional Keywords | purotoxin-1, toxin, p2x receptor |
| Biological source | Alopecosa marikovskyi (spiders) |
| Total number of polymer chains | 1 |
| Total formula weight | 3852.58 |
| Authors | Nadezhdin, K.,Vassilevski, A.,Arseniev, A.,Grishin, E.,Pluzhnikov, K.,Korolkova, Y. (deposition date: 2009-03-20, release date: 2010-03-31, Last modification date: 2024-11-27) |
| Primary citation | Grishin, E.V.,Savchenko, G.A.,Vassilevski, A.A.,Korolkova, Y.V.,Boychuk, Y.A.,Viatchenko-Karpinski, V.Y.,Nadezhdin, K.D.,Arseniev, A.S.,Pluzhnikov, K.A.,Kulyk, V.B.,Voitenko, N.V.,Krishtal, O.O. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann Neurol, 67:680-683, 2010 Cited by PubMed Abstract: P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain. PubMed: 20437566DOI: 10.1002/ana.21949 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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