2KGE

NMR Solution Structures of 3,5-dioxohexyl ACP (a triketide mimic) from the actinorhodin polyketide synthase in Streptomyces coelicolor

Summary for 2KGE

Entry DOI	10.2210/pdb2kge/pdb
Related	2k0x 2k0y 2kg6 2kg8 2kg9 2kga 2kgc 2kgd
NMR Information	BMRB: 16203
Descriptor	Actinorhodin polyketide synthase acyl carrier protein, N-{2-[(3,5-dioxohexyl)sulfanyl]ethyl}-N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide (2 entities in total)
Functional Keywords	acp, triketide, polyketide, actinorhodin, antibiotic biosynthesis, phosphopantetheine, biosynthetic protein
Biological source	Streptomyces coelicolor
Total number of polymer chains	1
Total formula weight	9709.65
Authors	Crump, M.P.,Evans, S.E.,Williams, C. (deposition date: 2009-03-08, release date: 2009-04-14, Last modification date: 2021-10-20)
Primary citation	Evans, S.E.,Williams, C.,Arthur, C.J.,Ploskon, E.,Wattana-Amorn, P.,Cox, R.J.,Crosby, J.,Willis, C.L.,Simpson, T.J.,Crump, M.P. Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389:511-528, 2009 Cited by PubMed: 19361520 DOI: 10.1016/j.jmb.2009.03.072 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation