2KG5

NMR Solution structure of ARAP3-SAM

2KG5 の概要

• エントリーDOI: 10.2210/pdb2kg5/pdb
• 分子名称: Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (1 entity in total)
• 機能のキーワード: sam domain, helix bundle, cell membrane, cell projection, cytoplasm, cytoskeleton, gtpase activation, membrane, metal-binding, phosphoprotein, polymorphism, zinc, zinc-finger, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q8WWN8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10864.16

構造登録者

Leone, M.,Pellecchia, M. (登録日: 2009-03-05, 公開日: 2009-11-17, 最終更新日: 2024-05-22)

主引用文献

Leone, M.,Cellitti, J.,Pellecchia, M.
The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam.
Bmc Struct.Biol., 9:59-59, 2009

PubMed Abstract: Sterile alpha motif (Sam) domains are small protein modules that can be involved in homotypic or heterotypic associations and exhibit different functions. Previous studies have demonstrated that the Sam domain of the lipid phosphatase Ship2 can hetero-dimerize with the Sam domain of the PI3K effector protein Arap3.

PubMed: 19765305
DOI: 10.1186/1472-6807-9-59

実験手法

SOLUTION NMR