2KD3

NMR structure of the Wnt modulator protein Sclerostin

2KD3 の概要

• エントリーDOI: 10.2210/pdb2kd3/pdb
• 分子名称: Sclerostin (1 entity in total)
• 機能のキーワード: protein, antagonist of cytokine, protein binding
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12711.73

構造登録者

Weidauer, S.E.,Mueller, T.D. (登録日: 2009-01-02, 公開日: 2009-02-10, 最終更新日: 2024-10-30)

主引用文献

Weidauer, S.E.,Schmieder, P.,Beerbaum, M.,Schmitz, W.,Oschkinat, H.,Mueller, T.D.
NMR structure of the Wnt modulator protein Sclerostin
Biochem.Biophys.Res.Commun., 380:160-165, 2009

PubMed Abstract: Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family. Recent findings, however, show that Sclerostin interferes with the Wnt signaling pathway due to binding to the Wnt co-receptor LRP5 thereby modulating bone growth. As Sclerostin is exclusively produced by osteocytes located in bones, neutralization of its bone-inhibiting functions makes it a highly interesting target for an osteoanabolic therapeutic approach in diseases characterized by bone loss, such as osteoporosis. Despite the huge interest in Sclerostin inhibitors the molecular basis of its function and its interaction with components of the Wnt signaling cascade has remained unclear. Here, we present the NMR structure of murine Sclerostin providing the first insights how Sclerostin might bind to LRP5.

PubMed: 19166819
DOI: 10.1016/j.bbrc.2009.01.062

実験手法

SOLUTION NMR