2KD2

NMR Structure of FAIM-CTD

2KD2 の概要

• エントリーDOI: 10.2210/pdb2kd2/pdb
• NMR情報: BMRB: 16103
• 分子名称: Fas apoptotic inhibitory molecule 1 (1 entity in total)
• 機能のキーワード: protein, beta sandwich, apoptosis
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm: Q9WUD8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10520.71

構造登録者

Hemond, M.,Wagner, G. (登録日: 2009-01-01, 公開日: 2009-02-10, 最終更新日: 2024-05-22)

主引用文献

Hemond, M.,Rothstein, T.L.,Wagner, G.
Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain.
J.Mol.Biol., 386:1024-1037, 2009

PubMed Abstract: Fas apoptosis inhibitory molecule (FAIM) is a soluble cytosolic protein inhibitor of programmed cell death and is found in organisms throughout the animal kingdom. A short isoform of FAIM is expressed in all tissue types, while an alternatively spliced long isoform is specifically expressed in the brain. Here, the short isoform is shown to consist of two independently folding domains in contact with each other. The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich. The structure and sequence reveal several residues that are likely to be involved in functionally significant interactions with the N-terminal domain or other binding partners. Chemical shift perturbation is used to elucidate contacts made between the N-terminal domain and the C-terminal domain.

PubMed: 19168072
DOI: 10.1016/j.jmb.2009.01.004

実験手法

SOLUTION NMR