2KBY

The Tetramerization Domain of Human p73

2KBY の概要

• エントリーDOI: 10.2210/pdb2kby/pdb
• 分子名称: Tumor protein p73 (1 entity in total)
• 機能のキーワード: tetramerization domain, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, dna-binding, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, zinc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O15350
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 24139.31

構造登録者

Coutandin, D.,Ikeya, T.,Loehr, F.,Guntert, P.,Ou, H.D.,Doetsch, V. (登録日: 2008-12-12, 公開日: 2009-09-29, 最終更新日: 2022-03-16)

• 主引用文献: Coutandin, D.,Lohr, F.,Niesen, F.H.,Ikeya, T.,Weber, T.A.,Schafer, B.,Zielonka, E.M.,Bullock, A.N.,Yang, A.,Guntert, P.,Knapp, S.,McKeon, F.,Ou, H.D.,Dotsch, V.; Conformational stability and activity of p73 require a second helix in the tetramerization domain.; Cell Death Differ., 16:1582-1589, 2009; PubMed: 19763140; DOI: 10.1038/cdd.2009.139

実験手法

SOLUTION NMR