2KBS

Solution structure of harmonin PDZ2 in complex with the carboxyl tail peptide of cadherin23

2KBS の概要

• エントリーDOI: 10.2210/pdb2kbs/pdb
• 関連するPDBエントリー: 2KBQ 2KBR
• 分子名称: Harmonin, octameric peptide from Cadherin-23 (2 entities in total)
• 機能のキーワード: protein complex, alternative splicing, coiled coil, deafness, hearing, non-syndromic deafness, polymorphism, retinitis pigmentosa, sensory transduction, usher syndrome, vision, calcium, cell adhesion, cell membrane, disease mutation, glycoprotein, membrane, phosphoprotein, transmembrane, structural protein-cell adhesion complex, structural protein/cell adhesion
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein (By similarity): Q9H251
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10593.19

構造登録者

Pan, L.,Yan, J.,Wu, L.,Zhang, M. (登録日: 2008-12-05, 公開日: 2009-03-31, 最終更新日: 2022-03-16)

• 主引用文献: Pan, L.,Yan, J.,Wu, L.,Zhang, M.; Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23; Proc.Natl.Acad.Sci.USA, 106:5575-5580, 2009; PubMed: 19297620; DOI: 10.1073/pnas.0901819106

実験手法

SOLUTION NMR