2KB9

Human Jagged-1, exon 6

Summary for 2KB9

• Entry DOI: 10.2210/pdb2kb9/pdb
• Related: 2VJ2
• NMR Information: BMRB: 16857
• Descriptor: Jagged-1 (1 entity in total)
• Functional Keywords: notch signaling, egf, calcium, developmental protein, disease mutation, egf-like domain, glycoprotein, membrane, notch signaling pathway, polymorphism, transmembrane, protein binding
• Cellular location: Membrane; Single-pass type I membrane protein: P78504
• Total number of polymer chains: 1
• Total formula weight: 5048.78

Authors

Pintar, A.,Guarnaccia, C.,Pongor, S. (deposition date: 2008-11-24, release date: 2009-07-28, Last modification date: 2022-03-16)

Primary citation

Pintar, A.,Guarnaccia, C.,Dhir, S.,Pongor, S.
Exon 6 of human JAG1 encodes a conserved structural unit
Bmc Struct.Biol., 9:43-43, 2009

PubMed Abstract: Notch signaling drives developmental processes in all metazoans. The receptor binding region of the human Notch ligand Jagged-1 is made of a DSL (Delta/Serrate/Lag-2) domain and two atypical epidermal growth factor (EGF) repeats encoded by two exons, exon 5 and 6, which are out of phase with respect to the EGF domain boundaries.

PubMed: 19586525
DOI: 10.1186/1472-6807-9-43

Experimental method

SOLUTION NMR