Loading
PDBj
メニューPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2K9H

The hantavirus glycoprotein G1 tail contains a dual CCHC-type classical zinc fingers

2K9H の概要
エントリーDOI10.2210/pdb2k9h/pdb
分子名称Glycoprotein, ZINC ION (2 entities in total)
機能のキーワードhantavirus, glycoprotein, zinc finger, cchc, metal binding protein
由来する生物種Andes virus
タンパク質・核酸の鎖数1
化学式量合計6475.06
構造登録者
Estrada, D.F.,Boudreaux, D.M.,Zhong, D.,St Jeor, S.C.,De Guzman, R.N. (登録日: 2008-10-13, 公開日: 2009-01-27, 最終更新日: 2024-05-22)
主引用文献Estrada, D.F.,Boudreaux, D.M.,Zhong, D.,St Jeor, S.C.,De Guzman, R.N.
The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers.
J.Biol.Chem., 284:8654-8660, 2009
Cited by
PubMed Abstract: Hantaviruses are distributed worldwide and can cause a hemorrhagic fever or a cardiopulmonary syndrome in humans. Mature virions consist of RNA genome, nucleocapsid protein, RNA polymerase, and two transmembrane glycoproteins, G1 and G2. The ectodomain of G1 is surface-exposed; however, it has a 142-residue C-terminal cytoplasmic tail that plays important roles in viral assembly and host-pathogen interaction. Here we show by NMR, circular dichroism spectroscopy, and mutagenesis that a highly conserved cysteine/histidine-rich region in the G1 tail of hantaviruses forms two CCHC-type classical zinc fingers. Unlike classical zinc fingers, however, the two G1 zinc fingers are intimately joined together, forming a compact domain with a unique fold. We discuss the implication of the hantaviral G1 zinc fingers in viral assembly and host-pathogen interaction.
PubMed: 19179334
DOI: 10.1074/jbc.M808081200
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 2k9h
検証レポート(詳細版)ダウンロードをダウンロード

238582

件を2025-07-09に公開中

PDB statisticsPDBj update infoContact PDBjnumon