2K94

Structural modification of acyl carrier protein by butyryl group

2K94 の概要

• エントリーDOI: 10.2210/pdb2k94/pdb
• 関連するPDBエントリー: 2K92 2K93
• 分子名称: Acyl carrier protein (1 entity in total)
• 機能のキーワード: butytyl form of acyl carrier protein, fatty acid synthesis protein, cytoplasm, fatty acid biosynthesis, lipid synthesis, phosphopantetheine, lipid transport
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A6A8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8513.28

構造登録者

Wu, B.N. (登録日: 2008-09-29, 公開日: 2009-01-20, 最終更新日: 2024-05-22)

主引用文献

Wu, B.N.,Zhang, Y.M.,Rock, C.O.,Zheng, J.J.
Structural modification of acyl carrier protein by butyryl group.
Protein Sci., 18:240-246, 2009

PubMed Abstract: Fatty acid synthesis in bacteria is catalyzed by a set of individual enzymes known as the type II fatty acid synthase. Acyl carrier protein (ACP) shuttles the acyl intermediates between individual pathway enzymes. In this study, we determined the solution structures of three different forms of ACP, apo-ACP, ACP, and butyryl-ACP under identical experimental conditions. The structural studies revealed that attachment of butyryl acyl intermediate to ACP alters the conformation of ACP. This finding supports the more general notion that the attachment of different acyl intermediates alters the ACP structure to facilitate their recognition and turnover by the appropriate target enzymes.

PubMed: 19177367
DOI: 10.1002/pro.11

実験手法

SOLUTION NMR