2K1A

Bicelle-embedded integrin alpha(IIB) transmembrane segment

2K1A の概要

• エントリーDOI: 10.2210/pdb2k1a/pdb
• 分子名称: Integrin alpha-IIb (1 entity in total)
• 機能のキーワード: single-pass transmembrane segment, alternative splicing, calcium, cell adhesion, cleavage on pair of basic residues, disease mutation, glycoprotein, integrin, polymorphism, pyrrolidone carboxylic acid, receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08514
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4751.83

構造登録者

Lau, T.-L.,Dua, V.,Ulmer, T.S. (登録日: 2008-02-25, 公開日: 2008-04-15, 最終更新日: 2024-05-29)

主引用文献

Lau, T.L.,Dua, V.,Ulmer, T.S.
Structure of the Integrin {alpha}IIb Transmembrane Segment.
J.Biol.Chem., 283:16162-16168, 2008

PubMed Abstract: Integrin cell-adhesion receptors transduce signals bidirectionally across the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit. While the beta3 transmembrane segment consists of a linear 29-residue alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-helix (Ile-966 -Lys-989) followed by a backbone reversal that packs Phe-992-Phe-993 against the transmembrane helix. The length of the alphaIIb transmembrane helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering beta3 subunit. Sequence alignment shows Gly-991-Phe-993 to be fully conserved among all 18 human integrin alpha subunits, suggesting that their unusual structural motif is prototypical for integrin alpha subunits. The alphaIIb transmembrane structure demonstrates a level of complexity within the membrane that is beyond simple transmembrane helices and forms the structural basis for assessing the extent of structural and topological rearrangements upon alphaIIb-beta3 association, i.e. integrin transmembrane signaling.

PubMed: 18417472
DOI: 10.1074/jbc.M801748200

実験手法

SOLUTION NMR