2K05
Structure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7, 12 and 21
Summary for 2K05
Entry DOI | 10.2210/pdb2k05/pdb |
Related | 2K01 2K03 2K04 |
NMR Information | BMRB: 15637 |
Descriptor | Stromal cell-derived factor 1, C-X-C chemokine receptor type 4 (2 entities in total) |
Functional Keywords | stromal cell derived factor-1, sdf1-alpha, cxcl12, cxcr4, chemokine, sulfotyrosine, locked dimer, alternative splicing, chemotaxis, cytokine, growth factor, secreted, g-protein coupled receptor, glycoprotein, host-virus interaction, membrane, receptor, sulfation, transducer, transmembrane |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 25895.44 |
Authors | Volkman, B.F.,Veldkamp, C.T.,Peterson, F.C. (deposition date: 2008-01-24, release date: 2008-10-28, Last modification date: 2023-11-15) |
Primary citation | Veldkamp, C.T.,Seibert, C.,Peterson, F.C.,De la Cruz, N.B.,Haugner, J.C.,Basnet, H.,Sakmar, T.P.,Volkman, B.F. Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci.Signal., 1:ra4-ra4, 2008 Cited by PubMed: 18799424DOI: 10.1126/scisignal.1160755 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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