2JXF

The solution structure of HCV NS4B(40-69)

2JXF の概要

• エントリーDOI: 10.2210/pdb2jxf/pdb
• NMR情報: BMRB: 15559
• 分子名称: Genome polyprotein (1 entity in total)
• 機能のキーワード: membrane associated segment, acetylation, apoptosis, atp-binding, capsid protein, cytoplasm, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, metal-binding, mitochondrion, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc, viral protein, membrane protein
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3601.12

構造登録者

Montserret, R.,Penin, F. (登録日: 2007-11-19, 公開日: 2008-11-25, 最終更新日: 2022-03-16)

• 主引用文献: Gouttenoire, J.,Castet, V.,Montserret, R.,Arora, N.,Raussens, V.,Ruysschaert, J.-M.,Diesis, E.,Blum, H.E.,Penin, F.,Moradpour, D.; Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B; J.Virol., 83:6257-6268, 2009; PubMed: 19357161; DOI: 10.1128/JVI.02663-08

実験手法

SOLUTION NMR