2JWA

ErbB2 transmembrane segment dimer spatial structure

2JWA の概要

• エントリーDOI: 10.2210/pdb2jwa/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2 (1 entity in total)
• 機能のキーワード: transmembrane helix dimer, erbb2, protein kinase receptor membrane domain, atp-binding, glycoprotein, nucleotide-binding, phosphorylation, polymorphism, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9469.61

構造登録者

Mineev, K.S.,Bocharov, E.V.,Arseniev, A.S. (登録日: 2007-10-09, 公開日: 2008-01-22, 最終更新日: 2024-05-29)

主引用文献

Bocharov, E.V.,Mineev, K.S.,Volynsky, P.E.,Ermolyuk, Y.S.,Tkach, E.N.,Sobol, A.G.,Chupin, V.V.,Kirpichnikov, M.P.,Efremov, R.G.,Arseniev, A.S.
Spatial Structure of the Dimeric Transmembrane Domain of the Growth Factor Receptor ErbB2 Presumably Corresponding to the Receptor Active State
J.Biol.Chem., 283:6950-6956, 2008

PubMed Abstract: Proper lateral dimerization of the transmembrane domains of receptor tyrosine kinases is required for biochemical signal transduction across the plasma membrane. The spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelles was obtained by solution NMR, followed by molecular dynamics relaxation in an explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif Thr652-X3-Ser656-X3-Gly660, providing an explanation for the pathogenic power of some oncogenic mutations.

PubMed: 18178548
DOI: 10.1074/jbc.M709202200

実験手法

SOLUTION NMR