2JSS

NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B

2JSS の概要

• エントリーDOI: 10.2210/pdb2jss/pdb
• 関連するPDBエントリー: 1YFQ
• NMR情報: BMRB: 15393
• 分子名称: Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W (2 entities in total)
• 機能のキーワード: histone-chaperone complex, intrinsically unfolded protein, chaperone-structural protein complex, chaperone-nuclear protein complex, chaperone/nuclear protein
• 由来する生物種: Saccharomyces cerevisiae (yeast); 詳細
• 細胞内の位置: Nucleus: Q12692 P40019
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28033.68

構造登録者

Zhou, Z.,Feng, H.,Hansen, D.F.,Kato, H.,Luk, E.,Freedberg, D.I.,Kay, L.E.,Wu, C.,Bai, Y. (登録日: 2007-07-11, 公開日: 2008-05-20, 最終更新日: 2024-05-29)

主引用文献

Zhou, Z.,Feng, H.,Hansen, D.F.,Kato, H.,Luk, E.,Freedberg, D.I.,Kay, L.E.,Wu, C.,Bai, Y.
NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Nat.Struct.Mol.Biol., 15:868-869, 2008

PubMed Abstract: The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.

PubMed: 18641662
DOI: 10.1038/nsmb.1465

実験手法

SOLUTION NMR